While PFO closure has been generally found to be very beneficial, it may not be for everyone. Some people may not be good candidates for PFO closure for one or more of the following reasons:
- They have other conditions that will explain the stroke such as significant carotid artery disease, or atrial fibrillation.
- Their work up identifies certain congenital irregularities or unexpected pathologies such as tumors or clots that would preclude them from having the procedure.
- They have a nickel allergy. Although this is not an absolute contraindication to having a PFO closure, it requires careful discussion of risks vs. benefits as well as device choice.