• Preeclampsia & Your Heart: An Early Warning Sign for Cardiovascular Disease

    11/22/2014

    You may think of preeclampsia—high blood pressure during or immediately following pregnancy—as a condition specific to pregnancy. However, research is finding that preeclampsia appears to be a significant warning sign for heart disease after pregnancy. In fact, the American Heart Association’s guidelines on cardiovascular disease in women consider preeclampsia as a risk factor for heart disease as strong as a failed stress test—a test commonly used to identify existing heart disease.

    Recognizing this important risk factor and the role of other pregnancy complications in later heart disease is vital to women’s heart health: Cardiovascular disease is the leading cause of death in women in the United States and Europe.

    Read on to learn more about the relationship between preeclampsia and later heart disease—and how you can make sure your physician is aware of your medical history to help you monitor your heart health appropriately.

    The Link Between Preeclampsia and Heart Disease

    Preeclampsia is a medical condition marked by high blood pressure during pregnancy and post-partum. The condition is typically treated with medications; however, if blood pressure does not respond to treatment, early delivery may be advised. According to the Preeclampsia Foundation, 5–8 percent of all pregnancies are affected, and preeclampsia is a leading cause of infant and mother illness and death worldwide.

    Research has found that preeclampsia can be an early indicator of future cardiovascular problems in women:

    • A history of preeclampsia doubles the risk of heart attack, stroke, and blood clots within 5–15 years after pregnancy.
    • Women who have repeat or severe preeclampsia or preeclampsia accompanied by stillbirth are at greater risk of cardiovascular disease than women who have high blood pressure only or preeclampsia during a single pregnancy.
    • Many women may not be aware that preeclampsia and other pregnancy complications can signal heart disease risk. A study found that 13 percent of women screened for heart disease risk factors during an OBGYN visit had three or more cardiovascular disease risk factors they were not aware of.

    Medical researchers do not yet know exactly how and why preeclampsia and future cardiovascular disease are linked. One theory is that the additional strain that pregnancy places on the cardiovascular system unmasks early existing cardiovascular disease. However, more research is necessary to understand the connection.

    What Does a History of Preeclampsia Mean for Diagnosis and Treatment of Cardiovascular Disease?

    As more physicians and patients become aware of the link between preeclampsia and future heart disease, women who are at risk can be identified earlier and treated sooner.

    If you are a woman who had preeclampsia during a pregnancy, make sure that your physician is aware that you have this heart disease risk factor. If you, like approximately 20 percent of women, use your OBGYN as your primary care physician, discuss your heart health with your OBGYN. Your primary care physician or OBGYN can help you determine next steps for your heart health if you had preeclampsia or other pregnancy complications that are linked with future heart disease, such as gestational diabetes or a preterm birth.

    Questions to Ask Your Health Care Provider about Preeclampsia and Heart Health

    • I had preeclampsia during one or more pregnancies. Should I be referred to a cardiologist?
    • What other risk factors do I have (other pregnancy complications, cholesterol, obesity, etc.), and how can I reduce my risk?
    • What actions should I be taking now to monitor my heart health?
    • Are there lab tests or diagnostic tests that you would recommend based on my history of preeclampsia and other risk factors?
    • Are there lifestyle or medication changes that would benefit my heart health?

    What Should I Do If I Have Other Questions?

    Ask them. Remember that though preeclampsia appears to be a risk factor for later cardiovascular disease, everyone is different. The key is to establish with your physician what your baseline cardiovascular health is now and make sure that your physician is aware that you had a pregnancy complication associated with later development of heart disease. Then, periodically ask your physician, “Have we checked my heart health recently?” Identifying and treating cardiovascular disease sooner rather than later will increase the odds of being able to work with your physician to slow or reverse the disease process.

    SecondsCount is pleased to also provide this information as a downloadable PDF. We invite you to print it and share it with others, including your healthcare providers.

    To download the PDF of this information, click here.

    To review a survey developed by Women in Innovations (WIN) and the Women’s Heart Health Initiative to help OBGYNs screen their patients for heart disease, click here.


    References

    Bellamy, L, Casas, J, Hingorani, AD, Williams, DJ. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. British Medical Journal. 2007;335:974–985.

    Brown MC, Bell R, Collins C, Waring G, Robson SC, Waugh J, Finch T. Women's perception of future risk following pregnancies complicated by preeclampsia. Hypertension in Pregnancy. 2012;32;60–73.

    Evans CS, Gooch L, Flotta D, Lykins D, Powers RW, et al. (2011) Cardiovascular system during the postpartum state in women with a history of preeclampsia. Hypertension. 2011;58:57–62.

    Fraser A, Nelson S, Macdonald-Wallis C, Cherry L, Butler E., et al. Associations of pregnancy complications with calculated CVD risk and cardiovascular risk factors in middle age: The Avon Longitudinal Study of Parents and Children. Circulation. 2012;125(11):1367–80.

    Kvehaughen AS, Dechend R, Ramstad HB, Troisi R, Fugelseth D, et al. Endothelial function and circulating biomarkers are disturbed in women and children after preeclampsia. Hypertension. 2011;58:63–69.

    Magee LA. Pre-eclampsia and increased cardiovascular risk. British Medical Journal. 2007;335:945–946.

    Magee LA, Newstead J, Ng J, Cote AM, Von Dadelszen P. Pre-eclampsia as a marker of cardiovascular disease. Fetal and Maternal Medicine Review. 2008;19(4): 271­–292.

    Männistö T, et al. Elevated blood pressure in pregnancy and subsequent chronic disease risk. Circulation. 2013;127(6):681–690.

    Marma AK, Berry JD, Ning H, Persell SD, Lloyd-Jones DM. Distribution of 10-year and lifetime predicted risks for cardiovascular disease in US adults: findings from the National Health and Nutrition Examination Survey 2003 to 2006. Circ Cardiovasc Qual Outcomes. 2010;3:8–14.

    Matsuzawa Y, Sugiyama S, Sugamura K, Nozaki T, Ohba K, et al. Digital assessment of endothelial function and ischemic heart disease in women. Journal of American College of Cardiology. 2010;55(16):1688–1696.

    Mosca L, Benjamin EJ, Berra K et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women - 2011 update: a guideline from the American Heart Association. Circulation. 2011;123(11):1243–1262.

    Mungee S, et al. Women Heart Health Initiative: collaborative effort is the key. SCAI 2012; Abstract B-029.

    Pell JP, Smith GCS, Walsh D. (2004). Pregnancy complications and subsequent maternal cerebrovascular events: a retrospective cohort study of 119,668 births. American Journal of Epidemiology. 2004;159:336–342.

    Ray JG, Vermeulen MJ, Schull MJ, Redelmeier DA. Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study. The Lancet. 2005;366:1797–1803.

    Robb AO, Mills NL, Din JN, Smith IBJ, Paterson F, et al. Influence of the menstrual cycle, pregnancy, and preeclampsia on arterial stiffness. Hypertension. 2009; 53: 952-958.

    Smith GC S, Pell JP, Walsh D. Pregnancy complications and maternal risk of ischemic heart disease: a retrospective cohort study of 129,290 births. The Lancet. 2001;357: 2002–2006.

    Vikse B, Irgens L, Leivestad T, Skjaerven R, Iversen B. Preeclampsia and the risk of end-stage renal disease. The New England Journal of Medicine. 2008; 359(8):800–809.

    Yinon Y, Kingdom J, Odutayo A, Moineddin R, Drewlo S, et al. Vascular Dysfunction in women with a history of preeclampsia and intrauterine growth restriction. Insights into future vascular risk. Circulation. 2010;122:1846–1853.