Your doctor will let you know whether you are a good candidate for PFO closure with a PFO occluder device. If you have a PFO and have suffered a cryptogenic stroke (meaning it is not attributed to a cause such as atrial fibrillation, carotid artery disease and so forth) and if your neurologist and interventional cardiologist have determined anticoagulant medications are not for you, then device closure of your PFO may be an excellent option for you. However, it is essential to remember that about 700,000 ischemic strokes occur per year, and that many of these do have identifiable causes; therefore, there are multiple ways of lowering the risk of a second stroke.