Mitral Valve Regurgitation

Causes

The mitral valve is a complex structure made up of the valve flaps (leaflets). There are fibers that support those leaflets (chordae tendineae or just chords) and papillary muscles that support the chords. Abnormalities or damage to any of these structures can cause mitral valve regurgitation.

The most common cause of mitral valve regurgitation is mitral valve prolapse, which is when part of the mitral valve slips back into the left atrium when the left ventricle squeezes (contracts) during a heartbeat. Mitral valve prolapse doesn’t always lead to regurgitation. In fact, many people who have mitral valve prolapse never develop severe leaking of the mitral valve. Also, some children are born with a cleft ("hole") in one of the mitral valve leaflets that causes the regurgitation.